Daily Fluid Consumption—How Much is Enough?

How much REST is enough?

Recent papers published in Nature by Guardavaccaro et al. and Westbrook et al. describe a nexus of two masters of negative regulation of protein levels. Both of these studies establish that the transcriptional repressor REST/NRSF is regulated by the highly versatile ubiquitin protein ligase (E3) SCF(beta-TrCP), adding a new dimension to the relationship between the ubiquitin-proteasome system a...

Is enough oxygen too much?

Human cells require O2 for their energy supply, and critical illness can threaten the efficient delivery of O2 in accordance with tissue metabolic needs. In the accompanying article, Martin and colleagues point out that hypoxia is a normal and well-tolerated stress during embryonic development. A better understanding of how fetal cells survive these conditions and how adult cells adapt to high ...

Escalation: How Much is Enough?

often the subject of fierce debate. Cost increases are determined by dynamic relationships between many factors, including acts of nature, interest rates, oil prices, global commodity markets, wars, wage rates, and the overall health of the economy, as well as supply and demand for the required goods or services. How much escalation is enough? Are the recent price increases temporary aberration...

Neonatal workforce: how much is enough?

How Much Vitamin D Is Enough?

of alendronate and vitamin D3 on fractional calcium absorption in a double-blind, randomized, placebo-controlled trial in postmenopausal osteoporotic women. the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. calcium absorption in severe vitamin D deficiency. The effect of vitamin D on calcium absorption in older women. A, et al. Vitamin D supplementat...